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Subsequent laboratory studies have explored its observed effects on senescent chondrocytes, endothelial cell senescence via p53 signaling, and senescent cancer-cell models

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This finding should not be interpreted as a new result but as convergent evidence, corroborating the primary item-level analyses

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a G protein-coupled receptor that mediates vision in dim light by controlling activity of transducin, a G protein an enzyme that catalyzes the conversion of ATP into cytoplasmic 3',5'-cyclic adenosine monophosphate (cAMP) an ion channel that allows transmembrane passage of calcium ions in a manner that is regulated the membrane voltage gradient proteins that bind G protein-coupled receptors to inhibit signaling through G protein activation and ultimately, to permanently terminate signaling by promoting endocytotic internalization and degradation of the receptor