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For example, For instance, nuclear localization of Nrf2 is persistently elevated in the substantia nigra of PD patients [197], whereas Nrf2 protein levels are reduced in the primary motor cortex and spinal cord of ALS patients [198]

Finally, pair biomarkers with microdomain-aware interventionstuning NOX/NOS activity, tempering RET and supporting mitochondrial quality control, modulating UPR^ER, controlling iron/ferroptosis and augmenting RSS where appropriatewhile co-prescribing lifestyle levers (structured exercise, nutrition and circadian hygiene) so that therapy is targeted to the where, when and how much of the redox problem and is titrated to objective readouts rather than symptoms alone (Chen et al

doi: 10.1016/j.cell.2015.07.047 210 PearsonR

KD, n = 6 mice

Mito-ATO improved the efficacy of PD-1 blockade immunotherapy 52