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Yes, tolerance is often reversible or manageable without discontinuing therapy

PMID: 40 MohamedH

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IBD primarily encompasses ulcerative colitis (UC) and Crohns disease (CD) ( Similar to CD, mouse models of experimental colitis trigger a Th1 type immune response, reflected by the infiltration of IFN-producing T cells in the colon ( via intrarectal instillation of the chemicals

Furthermore, for specific compounds, additional key mechanisms such as Fas-mediated signal transduction, loss of cellular redox homeostasis, ATP depletion, changes in ion channels, and activation of kinases and caspases, among others, have been highlighted