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GSSG was docked to the proximity of all five cysteine residues, with each binding site defined as the center of the cysteine ( i ) and adjacent residues ( i 1 )

Abbreviations PCOS Polycystic Ovary Syndrome IR Insulin Resistance BMI Body Mass Index LH Luteinizing Hormone FSH Follicle-Stimulating Hormone AMH Anti-Mllerian Hormone GnRH Gonadotropin-Releasing Hormone HG Hyperinsulinemia ACTH Adrenocorticotropic Hormone DHEA Dehydroepiandrosterone DHEAS Dehydroepiandrosterone Sulfate HOMA-IR Homeostatic Model Assessment of Insulin Resistance HDL High-Density Lipoprotein LDL Low-Density Lipoprotein VLDL Very Low-Density Lipoprotein TAC Total Antioxidant Capacity GSH Glutathione MDA Malondialdehyde SHBG Sex Hormone-Binding Globulin hs-CRP High-Sensitivity C-Reactive Protein TRPV1 Transient Receptor Potential Vanilloid 1 EPA Eicosapentaenoic Acid DHA Docosahexaenoic Acid CoQ10 Coenzyme Q10 NAC N-Acetyl Cysteine CrP Chromium Picolinate RCT Randomized Controlled Trial CC Clomiphene Citrate LCKD Low-Carbohydrate Ketogenic Diet GL Glycemic Load GI Glycemic Index PP Premature Pubarche SCAD Stable Coronary Artery Disease Author contributions Author Contributions StatementA.A.M.S

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To make sure the direction of effect we got is sensible we notice that with an overabundance of the oxidized form the tendency to be oxidized by oxygen is somewhat lower as seen by the fact that the redox potential is now closer than before to that of the oxygen/water electron exchanging pair (+0.82V)