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Phase I dose-escalation study of investigational agent MLN9708, an oral proteasome inhibitor, in patients (Pts) with relapsed or refractory (Rel/Ref) multiple myeloma (MM)

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cerevisiae was utilized to keep uniform expression of each construct in this work

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216 In mammalian cells with functional mitochondria and active mTORC1, 4E-BP1 is localized on polysomes attached to the rER, leading to the dissociation of eIF4E and its recruitment to the active translation initiation complex eIF4F, enabling protein synthesis

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