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In previous studies, TMAO, often used as a key metabolite in the study of microbial metabolome alterations in cardiovascular disease, has been shown to directly stimulate platelets by enhancing intracellular calcium release, among other pathways, causing platelet hyperreactivity, thereby increasing the risk of thrombus formation (50)

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El-Zein RA, Fenech M, Lopez MS, Spitz MR, Etzel CJ: Cytokinesis-blocked micronucleus cytome assay biomarkers identify lung cancer cases amongst smokers

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However, you need to be aware that anyone can encounter a KP skin condition, and it typically clears up by the age of 30