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Figure 3 The intraperitoneal administration of an SLC7A11 inhibitor in a laser-generated CNV model increased lipid peroxidation and triggered ferroptosis, leading to the expansion of the CNV area in ARPE-19 cells

IGF-1, which is short for insulin-like growth factor 1, is a hormone made by the liver

As such, FVII represents a convenient model for determining sirna-mediated downregulation of hepatocyte-derived proteins, as well as monitoring plasma concentrations and tissue distribution of the nucleic acid lipid particles and siRNA

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Its transdermal application is particularly beneficial for patients who may have difficulties with oral administration or for those seeking targeted treatment