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doi: 10.1007/s13148-010-0011-5

Indeed, our experiments indicated the possibility that Nrf2 activation mitigates anemia, which is caused by impaired production of the erythroid growth factor erythropoietin from injured kidneys, and moderates organ damage worsened by anemic hypoxia

S.LechleiterJ

Considering that the analog and isomer of ISA, alantolactone has been found to be a NLRP3 inhibitor (Li et al., 2023), ISA is probably an NLRP3 inhibitor that can mitigate multiple kinds of inflammatory responses