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This results in a greater amount of KBs compared to the kilocalories consumed, allowing the patient to consume larger amounts of carbohydrates and proteins, making the diet easier to adhere to

Meanwhile the drug species, combination and delivery strategies of cuproptosis inducers or inhibitors also await further exploration

The presence of fibrosis was negatively associated with SOCS3 gene promoter methylation and positively associated with mRNA expression of SOCS3, TXNIP, IL-6, and MCP-1, which are involved in oxidative stress, inflammation, and fibrogenesis [335]

Conclusion Multidrug resistance to chemotherapy drugs is one of the main obstacles in human cancer chemotherapy and has prompted intense research into discovering novel and innovative mechanisms that can overcome this barrier

As will be discussed, one mechanism which may connect thiol-metal binding to oxidative stress-mediated toxicity is specific of Hg, the cysteinyl-glycine bound form of which is able to deplete glutathione reservoirs by a catalytic process [34]