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These findings establish ferroptosis as a previously unrecognised, leptomeningeal niche-dependent therapeutic vulnerability, which may be leveraged through drug repurposing

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Simvastatin affected activated CD8 + T-cell-mediated killing of GC cells by inhibiting PD-L1 expression The WB results revealed that simvastatin inhibited the protein expression of PD-L1 in GC cells in a concentration-dependent manner (Fig

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In the chloroplast, during pathogen infections, ROS production can increase significantly, and GPX helps mitigate this stress by protecting photosynthetic components and potentially reducing PCD (Mbemba et al., 1985