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Quitting reduces delayed bone healing, spinal fusion non-union and postoperative complications

24 Numerous studies have shown that the dysregulation of TGF-1/Smad represents an important pathogenic pathway in various tissue fibrogenesis, including lung, liver and kidney fibrosis

Kim HY, Kim TJ, Kang L, Kim Y-J, Kang MK, Kim J, Ryu JH, Hyeon T, Yoon B-W, Ko S-B

Catechins are major constituents of tea of which the most abundant is epigallocatechin-3-gallate (EGCG) capable of inhibiting the growth and development of cancer cells

2a-ii), IPA administration significantly mitigated disease manifestations, including attenuated colon shortening, reduced histopathological scoring, upregulated ZO-1 , OCLN and Muc2 expression, and diminished Tnfa expression (Fig