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The establishment, maintenance and characterization of midbrain organoids from human floor plate neuronal progenitor cells derived from a healthy (ID number: #232) and a Parkinsons disease patient with triplication in the SNCA gene (ID number: #317) were previously described by Muwanigwa et al

The study provides a detailed mechanistic insight into the interplay between metabolic reprogramming, protein stability, and drug response in the context of obesity and cancer