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155 Hyperglycemia and dyslipidemia depolarize mitochondrial membranes, reducing ATP production and exacerbating an energy crisis while generating ROS

Dysregulation of ceramide metabolism in the brain has been linked to several brain pathologies, including neurodegenerative diseases such as Alzheimers and Parkinsons, and psychiatric disorders like anxiety disorders, depression, and schizophrenia, and neurological injuries (Samboln-Escobales et al., 2022