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Intraproteomic results revealed a significant decrease in hexokinase 2, hexokinase domain containing 1, and phosphofructokinase, an enzyme belonging to glycolysis (Figure 9)

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Several studies indicate that tumor cell metabolic reprogramming is governed by both inherent genetic alterations, such as the loss of tumor suppressors or the activation of oncogenes, and external influences from the tumor microenvironment, such as hypoxia, ROS, and other factors [49,50,51,52]