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demonstrated a sex-specific relationship in a longitudinal cohort of adolescents, in which female adolescents at risk for/with MDD showed reduced levels of neuroprotective KYN metabolites [46 ]

The limited success of targeted medication can be attributed to multiple factors, including cytokine interactions of this complex and convoluted system with immunological redundancy, translatability of animal models to humans, individual responses to therapy, and side effects of these therapeutic agents [1]

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Fetal death may occur and sometimes results in a temporary recovery

Absorbance was measured at 517 nm using a UVvis spectrophotometer (PerkinElmer Lambda 20, Waltham, MA, USA), with methanol serving as the blank