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Meanwhile, TB-500 supports studies which helps researchers explore

Administration of mineralocorticoid antagonists intracerebroventricularly or intrahippocampal infusion have been shown to increase the basal HPA axis activity as well as potentiate the initial rise of ACTH in response to stress (83,84)

This association may be explained by the increased expression of keratinocyte transglutaminase in psoriatic lesions 47 , and/or by the high rate of keratinocyte hyperproliferation characteristic of psoriasis that elevates the cellular demand for amino acids 48