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Over millions of years, these protective mechanisms became sophisticated enough to extend their benefits throughout the entire organism

In simple terms, with age, disease, or trauma the crystallin proteins in the eye lens are damaged and denatured allowing them to clump to together

The production of inflammatory cytokines causes microglial activation which could activate NF-B leading to more production of cytokines such as IL-1 and TNF- causing a strong inflammatory response, disrupting neuronal function, and finally, neuronal death

Briefly, HUVECs (5.0103 cells/cm2) in collagen-coated 24-well culture plates were treated with the abovementioned tube-induction medium containing EBC-1 supernatants (250 g/ml) at the indicated time points