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FOXO4-DRI, designed to disrupt the FOXO4-p53 interaction, was tested on senescent TM3 Leydig cells

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Cells were treated with 1 mM BSO to deplete GSH

Conversely, some studies show that a deficiency in vitamin B12 may cause appetite loss, potentially leading to weight loss if left untreated ( If youre low or deficient in B12, your healthcare provider will likely recommend oral vitamin B12 supplements or injections to increase your blood levels ( summary Low levels of vitamin B12 can cause megaloblastic anemia, which is characterized by shortness of breath, headaches, and fatigue

J Immunol (2001) 167(5):28318