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However, in addition to the activation of sGC and its downstream effectors such as protein kinase G, NO also mediates signaling by oxidative S-nitrosylation of cysteine residues to form S-nitrosothiol groups within target proteins ( As NOS becomes uncoupled, an accompanying shift from S-nitrosylation to tyrosine nitration occurs and is the direct product of the changing ratio between ambient NO and superoxide produced by the enzyme

We next asked whether the different impacts of impairing the glutathione and thioredoxin pathways are specific to yeast or also hold true in other eukaryotic systems

2026 J Cosmet Dermatol

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