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Consistent with this, combined treatment of macrophages with LPS and palmitate synergistically increases ceramide production, and this TLR4-dependent response induces IL-1 and TNF expression (92, 127)

The compounds that were effective across multiple models were further tested as single agents and in combination with a clinically relevant protocol mimicking COJEC 12 , the five-chemotherapy cocktail (cisplatin, vincristine, carboplatin, etoposide and cyclophosphamide) that is the first line of action to treat HR-NB patients set by the International Society of Pediatric OncologyEuropean Neuroblastoma (SIOPEN) 6

Mitochondrion 53:154157

Rev Environ Health 39:7790

eIF5A functions globally in translation elongation and termination