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Short NJ, Kantarjian H, Ravandi F, Huang X, Jain N, Sasaki K, Khouri R, Daver NG, Pemmaraju N, Khoury JD, Jorgensent JL, Alvarado Y, Konopleva MY, Garcia-Manero G, Kadia TM, Yilmaz ME, Borthakur GM, Burger JA , Kornblau SM, Wierda WG, DiNardo CD, Ferrajoli A, Jacob J, Rostykus M, Garris R, Ward M, Huang B, Encarnacion C, Loiselle C, O'Brien SM, Jabbour E

In most patients with EH, there is an imbalance between cardiac output and peripheral vascular resistance in favor of increased peripheral resistance caused mainly by persistent smooth muscle constriction in the small arterioles with subsequent thickening of the wall and narrowing of the lumen

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