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Upon activation, choline dehydrogenase (CHDH) accumulates on the outer mitochondrial membrane (OMM), interacts with p62, and recruits autophagy adapters to depolarized mitochondria

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Addressing current gaps through integrative, personalized approaches will be critical to advancing early diagnosis, mechanistic understanding, and targeted interventions

Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)