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CD300b and its adapter, DAP12, activated splenic tyrosine kinase (Syk) and PI3K upon binding to LPS and TLR4, promoting the dissociation of MyD88-TIRAP, which further inhibited the activation of the MEK1/2-ERK1/2 and NF-B pathways via AKT, thereby inhibiting the production of the anti-inflammatory factor IL-10 and driving the cytokine response and aggravating septic shock

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TCF7L1 regulates cytokine response and neuroendocrine differentiation of prostate cancer