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Injecting too quickly, using cold medication straight from the refrigerator, or repeatedly injecting into the same spot all increase the likelihood of nodule formation

A subcutaneous (SC) formulation of daratumumab is approved for use and can be administered over ~ 5 min (QW for 8 weeks, Q2W in weeks 924, and Q4W from week 25, as monotherapy or combined with Pd or lenalidomide-dexamethasone) [14]

Peterson LW, Artis D (2014) Intestinal epithelial cells: regulators of barrier function and immune homeostasis

For this reason, treatment should be based on a thorough medical evaluation, appropriate laboratory testing, proper dosing, and ongoing monitoring by a qualified healthcare provider