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Other COPD intervention studies are underway to examine the effect(s) of 3,000 6,000 IU of vitamin D3 on rehabilitation (NCT01416701), as well as time to first upper respiratory infection and first moderate-to-severe exacerbation (NCT00977873) (clinicaltrials.gov 2012)

Metabolite ratios have been successfully used in newborn screening for inherited metabolic disorders such as phenylketonuria, maple syrup urine disease, and certain disorders of organic acid or of mitochondrial fatty acid metabolism (35, 36) as well as in identifying metabolic underpinnings of more complex, multifactorial biological processes (37, 38)

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Linus Pauling Institute, 2012

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