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Advanced methods in biochemical genetics and metabolomics over the past 65 years have shown that many metabolic changes can be found in children and adults with ASD, but the specific differences change by age, sex, and severity of symptoms 3,4,5,6,7,8,9

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Within its 539 amino acids, two independent activation domains have been identified: activation function 1 (AF-1) (located between residues 103 and 372) that is essential for transcriptional activity of full-length androgen receptor, and activation function 5 (AF-5) (located between residues 362-486) that is required for transactivity of a constitutively active androgen receptor, which lacks its LBD (103)

These findings underscore EGFR, GSK3B, and STAT3, for carbamazepine and PTGS2, mTOR, and TLR4 for valproic-acid as pivotal therapeutic targets in oxidative stress-associated epilepsy

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