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Melatonin, known for its antioxidant properties, also modulates the Nrf2 pathway, enhancing the expression of heme oxygenase-1 (HO-1), which strengthens antioxidant defenses in DN (Negi et al., 2011a)

31 , e80 (2017)

TABLE 2 Summary of microbial metabolites of EC involved in anti-inflammatory activity

In addition, the inhibition of Th17 differentiation mediated by butyrate may be achieved through the activation of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and the suppression of IL-6 receptor (IL-6R) expression (67)