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PLoS One 19 , e0305651 (2024)

In many cancers, wild-type p53 is functionally inactivated through binding of negative regulators (e.g., MDM2/MDMX) to its transactivation domain (TAD), making disruption of these interactions a key therapeutic strategy

Geography Beneficiaries in some geographic areasparticularly rural areas or areas with concentrated povertyoften have difficulty accessing care