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Several CoQ biosynthesis genes have been implicated in epilepsy including COQ1-PDSS2 , COQ2 , COQ4 , COQ5 , COQ6 , COQ8-ADCK3 , COQ8-ADCK4 , and COQ9 , with COQ2 , COQ4 , and COQ8-ADCK3 mutations being more frequently associated with seizures (124)

Oral ivermectin disposition is affected in horses by concomitant administration with antihistamines, including fexofenadine and cetirizine, which is in line with the well-known transporter-mediated interactions with systemic exposure (94, 95)

Having elucidated the ferroptosis-immune-metabolism axis as a key self-sustaining mechanism in COPD pathogenesis, these insights provide a foundation for novel therapeutic interventions

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