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Additionally, Fe(II) augments TET enzyme activity, and vitamin C further amplifies this effect when Fe(III) is present

Weiner-Megnagi Z, Ben-Shlomo I, Goldberg Y, Shalev E

More metabolic parameters, such as fumarate, -KG, GLUT1, glycolytic enzymes (e.g., PKM2, hexokinase, pyruvate dehydrogenase), FAS-associated enzymes (e.g., fatty acid synthase, acetyl-CoA carboxylase), and other amino acids (e.g., tryptophan, methionine), also undergo significant alteration in the metabolic adaptation of macrophages [24, 303,304,305,306] and can serve as theoretical targets for innovative therapies

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