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Finally, the mixture was centrifuged at 5000 rpm/min for 10 min

Moreover, increased cellular uptake of Zn 2+ through the upregulation of zinc transporter ZIP8 activates metal-regulatory transcription factor-1 (MTF1), which in turn induces the expression of matrix-degrading enzymes in chondrocytes 33,83

[DOI] [PubMed] [Google Scholar] 8.Ellis RA, Moretti G

A comparison study focused on cytotoxicity, DNA damage, and oxidative stress of different metal oxide NPs (CuO, TiO 2 , ZnO, CuZnFe 2 O 4 , Fe 3 O 4 , Fe 2 O 3 ) in human lung epithelial cell line A549