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Likewise, the studies utilizing serum markers of fibrosis and histology have demonstrated coffee consumption inversely related to fibrosis in patients with NAFLD [53,72,73]

For instance, engineered heart tissues exposed to prolonged afterload or continuous neurohormonal stimulation, such as norepinephrine or transforming growth factor- (TGF-), exhibit progressive contractile decline, prolonged calcium transients, and arrhythmic bursts, which are characteristic of heart failure and maladaptive remodeling

To facilitate comparison across tumor types, we summarized representative DTP-associated molecular markers and transcriptional signatures across major cancer contexts ( Table 2 )

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