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This multi-targeted approach, embracing the MGBA, aligns with the emerging view of neurodegenerative diseases as whole-body disorders that require system-level interventions

Martino, P

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Using various biochemical and biophysical approaches, we demonstrate that Syn WT engages in functional interactions, whereas C-terminal acidic tail truncated Syn 1103 and S129-phosphomimicking ( S129E ) mutant are reactive, displaying broad, non-functional aberrant binding and impairing chaperone-mediated refolding

Mobile Phase Order No.: 66001Glutathione in Whole Blood - HPLC Glutathione Whole Blood Calibration Standard Order No.: 66003Glutathione in Whole Blood - HPLC Internal Standard Order No.: 66004Glutathione in Whole Blood - HPLC Precipitation Reagent Order No.: 66005Glutathione in Whole Blood - HPLC Derivatisation Reagent 1 (lyoph.) Order No.: 66006Glutathione in Whole Blood - HPLC Derivatisation Reagent 2 Order No.: 66007Glutathione in Whole Blood - HPLC Reduction Reagent Order No.: 66008Glutathione in Whole Blood - HPLC Reaction Vials, 1.5 ml Order No.: 33005Amber colour, light protected HPLC Column Glutathione in Whole Blood Order No.: 66100Glutathione in Whole Blood - HPLC Glutathione Whole Blood Controls Order No.: 0077/0078/0079 Precolumn Cartridge 4/10 Order No.: 18066Glutathione in Whole Blood - HPLC Glutathione Whole Blood Calibration Standard Order No.: 66003Glutathione in Whole Blood - HPLC Glutathione Whole Blood Controls Order No.: 0077/0078/0079 HPLC Column Glutathione in Whole Blood Order No.: 66100Glutathione in Whole Blood - HPLC PEEK Prefilter Housing Order no.: 15010 PEEK-encased Prefilter 5 m Order no.: 15009 Precolumn Cartridge Holder 4/10 Order no.: 18001 Free Glutathione (GSH) Glutathionedisulfide (GSSG) Clinical relevance Glutathione is a tripeptide, which is present in nearly all cells at high concentrations and is one of the most important antioxidant substances in the body