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Here are some common causes: Dietary deficiency, mainly in vegans and vegetarians Pernicious anemia, an autoimmune issue with intrinsic factor production Gastric disorders, like atrophic gastritis or gastrectomy Malabsorption conditions, including Crohns disease and celiac disease Certain medications, like proton pump inhibitors and metformin Signs and Symptoms Requiring Medical Intervention Its important to know the signs of vitamin B12 deficiency

Metabolic adaptation A compensatory reduction in energy expenditure that exceeds that predicted from changes in body mass and body composition during and after weight loss

5.1.7 Calycosin Calycosin is a flavonoid of Astragalus membranaceus, which is one of the effective active components of Astragalus membranaceus and has anti-inflammatory, anti-tumor, hypoglycemic and cardioprotective properties (104, 105)

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