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The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide

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The underlying mechanism(s) linking reduced IGF-1 signaling to improved mammalian lifespan is thought to involve improved stress defenses and lower risk for proliferative diseases 9,10,11 , though the reason for sex differences in this response remains unresolved

J Biol Chem 253:88548859 Tomisawa H, Suzuki S, Ichihara S, Fukuzawa H, Tateishi M (1984) Purification and characterization of a C-S lyase from Fusobacterium varium