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Pain Processing and Hyperalgesia During Opiate Withdrawal Opiate withdrawal is often described as intensely painful, even in individuals who did not originally use opioids for chronic pain

Methods: Six- to eight-week-old male and female Liver FXR knockout (( Fxr floxed/floxed , albumin Cre (+), Fxr LKO) and control (Cre-) mice were fed either a low-fat control diet or a NASH Fast Food (FF) diet (Western diet with 21% milk fat, 1.25% cholesterol, and 34% sucrose) both supplemented with 0.1% (w/w) UDCA for 16 weeks

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10.1038/clpt.1990.60 17 BenturY.McGuiganM.KorenG

The infusion is typically well-tolerated and takes approximately 60-90 minutes to complete