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Considering these requirements, CBD presents many challenges when it comes to use in topical formulations, especially with regard to CBDs extreme lipophilicity (LogP = 5.79), that may lead to its accumulation in the sebaceous glands, forming depots in the stratum corneum, as it tends to penetrate through the transfollicular route

Accordingly, an association between the SNP rs2631365-TC located in the promotor region of OCTN2 and failure of imatinib treatment has been described (Jaruskova et al., 2017)

Nat Rev Cardiol (2013) 10(8):45364

Definition of hyperprogression Hyperprogression was defined using the previously established criteria for solid tumors as progressive disease in the first 8 weeks after treatment initiation, a 10 mm minimum increase in the measurable lesions, plus: (i) an increase of 40% in the sum of target lesions compared with baseline and/or (ii) an increase of 20% in the sum of the target lesions compared with baseline plus the appearance of new lesions in at least two different organs

A composition comprising all the ingredients of Formulation W