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Minutes after initial stimulation, neutrophils switch from primarily using glycolysis for basal metabolism, to the PPP, in order to allow for rapid generation of NADPH ( Brisk production of NADPH through the PPP is itself linked to sufficient basal and reserve capacity of G6PD enzyme activity ( Figure 1A )

doi: 10.1186/s40478-020-00956-z

[250] Some patients may experience temporary sleep disruption when discontinuing long-term melatonin use, particularly if underlying sleep disorders have not been addressed