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Lactate also protects neurons during metabolic stress and influences gene expression related to plasticity [298]

Besides, clinical and neuroimaging studies, fluorodeoxyglucose positron emission tomography, cerebrospinal fluid biomarkers, and peripheral metabolic profiling all support the notion that metabolic impairment is an early and clinically relevant feature of AD very convincingly

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In Ca2+ and calmodulin-dependent activities, bilirubin increased voltage-gated calcium currents through high voltage-activated P/Q-type calcium channels [21]