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It should be noted that the G1228 is located far away from all 3 sites, (D, G1 and G2), validating the independence of the mechanism of GSH efflux stimulation relying on G1228 from the basal GSH transport and GSH-dependent transport of drugs

A longer survival time and higher body weight were reported in both group of animals

Hepatoprotective role of zinc sulphate in acetaminophen-induced liver toxicity

DNA extraction was carried out using the DNeasy Blood & Tissue Kit (Qiagen Ltd) according to the manufacturer's instructions, as described previously (Morphew et al ., Reference Morphew, Eccleston, Wilkinson, McGarry, Perally, Prescott, Ward, Williams, Paterson, Raman and Ravikumar2012) and the concentration and purity of the extracted DNA quantified using NanoDrop (ThermoFisher Scientific, USA)