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Indeed, a review of the preclinical evidence for MET inhibitors in pancreatic cancer acknowledged that none of the preclinical cancer models had considered the role of the stroma in MET/HGF pathway signalling [91]

Storage Requirements Unreconstituted lyophilized powder remains stable refrigerated at 2 to 8 degrees Celsius for up to 24 months or at room temperature for 90 plus days

Usually mild and improves over the first few weeks

If using monotherapy at 4.5 mg/week, vial counts roughly double from the 2.4 mg/week math above

We addressed this by developing compatible packaging and sterilization processes and testing packaged devices in accelerated and real-time ISO shelf-life stability studies, to compare optical, mechanical, chemical and sterility properties of the fully packaged BPCDX as-made and after storage for up to two years