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Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

CD38 is also important in acute lymphoblastic leukemia (ALL), an aggressive cancer of B or T lymphoblasts characterized by uncontrolled proliferation of immature lymphocytes [25]

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Typical trigeminal neuralgia with clinically relevant vascular compression often has a good chance of long-term relief with appropriate medication or microvascular decompression, while atypical, constant, post-dental, viral-related, or treatment-resistant facial pain usually requires a more individualized pain-control strategy

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