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In some embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increases intracellular NAD+ levels to provide muscular therapy

Mechanistic work shows it counters oxidative stress by boosting superoxide dismutase and catalase activities

It is formulated with Vitamin B12, which helps produce red blood cells and maintain a healthy nervous system