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Description

Eprenetapopt/APR-246/PRIMA-1 MET is a small molecule drug which has been proposed to bind to cystine residues in mutant p53, thermodynamically stabilizing it such that both WT conformation and functionality is restored [9]

Sandhu MS, Heald AH, Gibson JM, Cruickshank JK, Dunger DB, Wareham NJ: Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study