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Description

In mammals, mitochondrial fusion machinery is controlled by two Dynamin family guanosine triphosphatases (GTPases): mitofusin 1 (MFN1) and mitofusin 2 (MFN2) that mediate the fusion of outer membrane and optic atrophy protein 1 (OPA1) for the inner membrane (156, 157)

FLI also predicts NAFLDs extrahepatic complications including cardiometabolic risk, atherosclerosis, T2D, CKD, extrahepatic cancers, and mortality [93] , further supporting a role for GGT as a cardiometabolic biomarker