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Sermorelin is the unmodified GHRH(1-29) fragment with the shortest half-life

Bulow B, Hagmar L, Mikoczy Z, Nordstrom CH, Erfurth EM: Increased cerebrovascular mortality in patients with hypopituitarism

Variants with extended half-life have been explored for their capacity to sustain elevated growth hormone signaling over longer periods while preserving pulsatility