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About this article Cite this article Zejnullahu, V.A., Zejnullahu, V.A

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Even if cytokines were meaningful peripheral biomarkers: Blood cannot be compared to cerebrospinal fluid Even within blood sampling: Venous and arterial blood samples cannot be compared Even if blood sampling methods were equal: Plasma, serum, and PBMC sample matrices cannot be compared Even if ME/CFS researchers use a consistent sample matrix: Bioassay, ELISA, and multiplex assay results cannot be compared, even across kits of the same assay type Even if ME/CFS researchers standardize their methods: The same exact lab, personnel, and protocol will likely get different results from the same manufacturer's kit The relevant details of methods used in previous studies of cytokines in ME/CFS are listed in Table A1

We showed that cirrhotic (an IGF-1 deficiency condition) rats had diminished amino acid and glucose intestinal absorption [114, 194, 195] and that IGF-1 replacement therapy was able to restore both alterations, suggesting a role of IGF-1 in the position of transporters [196]

Laboratory investigations demonstrate that GHK-Cu exhibits a copper binding affinity (log K = 16.1) that positions it perfectly within the physiological copper transport hierarchystronger than albumin but weaker than ceruloplasminenabling controlled copper transfer to cellular targets