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Specifically, increase of caspase-9, apoptosis, mitochondrial reactive free oxygen species (fROS), lipid peroxidation, glutathione (GSH), transient receptor potential vanilloid-1 (TRPV1) current density, and calcium concentrations in the DRG and hippocampus was detected in STZ-induced diabetic peripheral mechanical allodynia and thermal hyperalgesia (Siniscalco et al., 2008)

Results are not instant and are maintained only while treatment and good sun protection continue