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The use of machine-learning algorithms applied to a wide range of biomarkers in HFpEF cohorts has identified several clusters a with different cardiovascular phenotypes and outcomes.163,164 Conclusion The pathophysiological basis for identifying and classifying HFpEF based on a multimarker strategy seems logical and deserves further research

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Phylogenetic tree was constructed using the Neighbour-Joining method in MEGA 7.0 with 1000 bootstrap replicates [70]

However, more evidence for the relation between RAS mutation and erastin sensibility cannot be found in some cancer cell lines (Yang et al., 2014)

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