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Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis

SOD converts superoxide to hydrogen peroxide: 2O 2 - + 2H + H 2 O 2 + O 2 The hydrogen peroxide is detoxified by the combined action of ascorbate peroxidase, dehydroascorbate reductase and glutathione reductase as mentioned in Lecture 17: Many other toxic substances taken in by organisms from the environment ( xenobiotics ) are detoxified by reaction with glutathione